SOME CYP450 INTERACTIONS

SUBSTRATES
INHIBITORS
INDUCERS

CYP1A2
alosetron (Lotronex)
caffeine
clomipramine (Anafranil)
clozapine (Clozaril)
duloxetine (Cymbalta)
ramelteon (Rozerem)
sertraline (Zoloft)
theophylline (Theo-Dur)
tizanidine (Zanaflex)
Strong:
fluvoxamine (Luvox)
Moderate:
ciprofloxacin (Cipro)
mexilitine (Mexetil)
propafenone (Rhythmol)
zileuton (Zyflo)
Weak:
acyclovir (Zovirax)
cimetidine (Tagamet)
famotidine (Pepcid)
norfloxacin (Noroxin)
verapamil (Calan)
omeprazole (Prilosec)
tobacco

CYP2C8
repaglinide (Prandin)
paclitaxel (Taxol)
Strong:
gemfibrozil (Lopid)
Weak:
trimethoprim

CYP2C9
alosetron (Lotronex)
diclofenac (Voltaren)
ibuprofen (Motrin)
piroxicam (Feldene)
losartan (Cozaar)
irbesartan (Avapro)
celecoxib (Celebrex)
phenytoin (Dilantin)
ramelteon (Rozerem)
tolbutamide (Orinase)
tamoxifen (Nolvadex)
warfarin (Coumadin)
Moderate:
amiodarone (Cordarone)
fluconazole (Diflucan)
fluvastatin (Lescol)
imatinib (Gleevec)
oxandrolone (Oxandrin)
zafirlukast (Accolate)
rifampin (Rifadin)

CYP2C19
Proton Pump Inhibitors:
lansoprazole (Prevacid)
omeprazole (Prilosec)
pantoprazole (Protonix)
Other:
diazepam (Valium)
nelfinavir (Viracept)
phenytoin (Dilantin)
voriconazole (Vfend)
Strong:
omeprazole (Prilosec)
Moderate:
cimetidine (Tagamet)
fluvoxamine (Luvox)
isoniazid (INH)
rifampin (Rifadin)

CYP2D6
Antidepressants:
amitriptyline (Elavil)
desipramine (Norpramin)
duloxetine (Cymbalta)
imipramine (Tofranil)
paroxetine (Paxil)
Antipsychotics:
aripiprazole (Abilify)
haloperidol (Haldol)
risperidone (Risperdal)
thioridazine (Mellaril)
Antiarrythmics:
mexiletine (Mexitil)
propafenone (Rythmol)
Beta-blockers:
propranolol (Inderal)
metoprolol (Lopressor, Toprol XL)
timolol (Blocarden)
Narcotics:
codeine
dextromethorphan
hydrocodone (Vicodin)
Others:
atomoxetine (Strattera)
tramadol (Ultram, Ultracet)
Strong:
fluoxetine (Prozac)
paroxetine (Paxil)
quinidine (Quinidex)
Moderate:
cimetidine (Tagamet)
duloxetine (Cymbalta)
haloperidol (Haldol)
imatinib (Gleevec)
ritonavir (Norvir)
terbinafine (Lamisil)
Weak:
amiodarone (Cordarone)
sertraline (Zoloft)

CYP3A
Anticholinergics:
darifenacin (Enablex)
oxybutynin (Ditropan)
solifenacin (Vesicare)
tolterodine (Detrol)
Benzodiazepines:
alprazolam (Xanax)
midazolam (Versed)
triazolam (Halcion)
Calcium channel blockers:
diltiazem (Cardizem)
felodipine (Plendil)
nimodipine (Nimotop)
nifedipine (Adalat)
nisoldipine (Sular)
nitrendipine
verapamil (Calan)
Chemotherapeutic agents:
cyclophosphamide (Cytoxan)
erlotinib (Tarceva)
ifosfamide (Ifex)
tamoxifen (Nolvadex)
vinblastine (Velban)
vincristine (Oncovin)
HIV drugs:
amprenavir (Agenerase)
atazanavir (Reyataz)
indinavir (Crixivan)
nelfinavir (Viracept)
ritonavir (Norvir)
saquinavir (Invirase, Fortovase)
tipranavir (Aptivus)
delavirdine (Rescriptor)
efavirenz (Sustiva)
nevirapine (Viramune)
HMG-CoA Reductase Inhibitors:
atorvastatin (Lipitor)
lovastatin (Mevacor)
simvastatin (Zocor)
Immunosuppressive agents:
cyclosporine (Neoral, Sandimmune)
tacrolimus (Prograf)
sirolimus (Rapamune)
Macrolide-type antibiotics:
clarithromycin (Biaxin)
erythromycin (Erythrocin)
telithromycin (Ketek)
troleandomycin (TAO)
Opioids:
alfentanil (Alfenta)
fentanyl (Sublimaze)
sufentanil (Sufenta)
Steroids:
budesonide (Pulmicort)
cortisol
17 Ŗ-estradiol
fluticasone (Flovent, Flonase)
progesterone
Others:
amiodarone (Cordarone)
astemizole (Hismanal)
buspirone (Buspar)
carbamazepine (Tegretol)
cisapride (Propulsid)
conivaptan (Vaprisol)
eletriptan (Relpax)
eplerenone (Inspra)
ergotamine
dihydroergotamine
pimozide (Orap)
quinidine (Quinidex)
ramelteon (Rozerem)
ranolazine (Ranexa)
repaglinide (Prandin)
sildenafil (Viagra)
tadalafil (Cialis)
terfenadine (Seldane)
trazodone (Desyrel)
vardenafil (Levitra)
Strong:
atazanavir (Reyataz)
cisapride (Propulsid)
clarithromycin (Biaxin)
conivaptan (Vaprisol)
indinavir (Crixivan)
itraconazole (Sporanox)
ketoconazole (Nizoral)
nefazodone (Serzone)
nelfinavir (Viracept)
ritonavir (Norvir)
saquinavir (Invirase, Fortovase)
telithromycin (Ketek)
troleandomycin (TAO)
Moderate:
amiodarone (Cordarone)
amprenavir (Agenerase)
aprepitant (Emend)
ciprofloxacin (Cipro)
diltiazem (Cardizem)
erythromycin (Erythrocin)
fluconazole (Diflucan)
fosamprenavir (Lexiva)
grapefruit juice
norfloxacin (Noroxin)
verapamil (Calan)
voriconazole (Vfend)
carbamazepine (Tegretol)
efavirenz (Sustiva)
nevirapine (Viramune)
phenytoin (Dilantin)
phenobarbital
rifabutin (Mycobutin)
rifapentine (Priftin)
rifampin (Rifadin)
St. Johnís Wort